Continuous flow photocatalysis enhanced using an aluminum mirror: rapid and selective synthesis of 2'-deoxy and 2',3'-dideoxynucleosides.
نویسندگان
چکیده
A unique photochemical flow reactor featuring quartz tubing, an aluminum mirror and temperature control has been developed for the photo-induced electron-transfer deoxygenation reaction to produce 2'-deoxy and 2',3'-dideoxynucleosides. The continuous flow format significantly increased the efficiency and selectivity of the reaction.
منابع مشابه
Continuous Flow Photochemistry for the Rapid and Selective Syn- thesis of 2’-Deoxy and 2’,3’-Dideoxynucleosides
Deoxynucleosides have demonstrated prominent antiviral and antitumoral activities, [1] leading to the development of several drugs, including but not limited to zidovudine, stavudine, trifluridine, idoxuridine, cladribine and didanosine (Fig. 1). Extraction from natural sources and fermentation processes can only provide a limited number of naturally-occurring 2’-deoxynucleosides; therefore, sy...
متن کاملUsing selective sequential extraction techniques to evaluate tendency of soil fractions in Cd removal by Fe3O4 nanoparticles in continuous flow system
Use of nanotechnology has proven to be a promising approach toward remediation of all phases of environment. The aim of this work is to investigate the effects of different parameters on using iron III oxide nanoparticles in a continuous flow configuration for the removal of Cd2+ ionsfrom contaminated soils. Also selective sequential extraction tests are carried out to evaluate the nanoparticle...
متن کاملLiquid Fuel Production from Synthesis Gas via Fermentation Process in a Continuous Tank Bioreactor (CSTBR) Using Clostridium ljungdahlii
The potential bioconversion of synthesis gas (syngas) to fuels and chemicals by microbial cell has attracted considerable attention in past decade. The feasibility of enhancing syngas bioconversion to ethanol and acetate using Clostridium ljungdahlii in a continuous tank bioreactor (CSTBR), kinetics and mass transfer coefficient of carbon monoxide (CO) utilization were evaluated. Two different ...
متن کاملSimulation of Material Plastic Flow and Morphology During Friction Stir Welding of Stainless Steel to Aluminum Alloy Dissimilar Joint
Today, steel to aluminum joints are used to facilitate transportation and fuel consumption. These joints are applied from nuclear, aerospace and naval to automobile and kitchen industries. According to previous studies fusion welding processes are not suitable methods for these joints, solid-state welding, especially friction stir welding, is a proper way to use for these joints. However, using...
متن کاملAn improved synthesis and preliminary biodistribution study of a Technetium-99m-labeled 2-amino-2-deoxy(thioacetyl)-D-glucose complex ([99mTc]-TA-DG) as a tumor imaging agent
Introduction: This report describes the synthesis of 2-Amino-2-deoxy(S-benzoylthioacetyl)-D-glucose (S-Bz-TA-DG), radiolabeled with [99mTc(CO)3(OH2)3]+ complex with a procedure including deprotection of the benzoyl group, characterization by HPLC using a C18 reverse phase column and preliminary biodistribution study in normal ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Chemical communications
دوره 48 60 شماره
صفحات -
تاریخ انتشار 2012